Elisabetta Moroni
Elisabetta Moroni
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta"- SCITEC CNR
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Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy
R Ronca, A Giacomini, E Di Salle, D Coltrini, K Pagano, L Ragona, ...
Cancer cell 28 (2), 225-239, 2015
Allosteric modulators of HSP90 and HSP70: dynamics meets function through structure-based drug design
M Ferraro, I D’Annessa, E Moroni, G Morra, A Paladino, S Rinaldi, ...
Journal of medicinal chemistry 62 (1), 60-87, 2018
Molecular dynamics simulations reveal the mechanisms of allosteric activation of Hsp90 by designed ligands
G Vettoretti, E Moroni, S Sattin, J Tao, DA Agard, A Bernardi, G Colombo
Scientific reports 6 (1), 23830, 2016
Activation of Hsp90 enzymatic activity and conformational dynamics through rationally designed allosteric ligands
S Sattin, J Tao, G Vettoretti, E Moroni, M Pennati, A Lopergolo, L Morelli, ...
Chemistry–A European Journal 21 (39), 13598-13608, 2015
Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin
M Andreini, D Doknic, I Sutkeviciute, JJ Reina, J Duan, E Chabrol, ...
Organic & biomolecular chemistry 9 (16), 5778-5786, 2011
Allosteric regulation points control the conformational dynamics of the molecular chaperone Hsp90
A Rehn, E Moroni, BK Zierer, F Tippel, G Morra, C John, K Richter, ...
Journal of Molecular Biology 428 (22), 4559-4571, 2016
Rational design of allosteric and selective inhibitors of the molecular chaperone TRAP1
C Sanchez-Martin, E Moroni, M Ferraro, C Laquatra, G Cannino, ...
Cell reports 31 (3), 2020
Exploiting conformational dynamics in drug discovery: design of C-terminal inhibitors of Hsp90 with improved activities
E Moroni, H Zhao, BSJ Blagg, G Colombo
Journal of chemical information and modeling 54 (1), 195-208, 2014
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
P Seneci, A Bianchi, C Battaglia, L Belvisi, M Bolognesi, A Caprini, ...
Bioorganic & medicinal chemistry 17 (16), 5834-5856, 2009
The structural asymmetry of mitochondrial Hsp90 (Trap1) determines fine tuning of functional dynamics
E Moroni, DA Agard, G Colombo
Journal of Chemical Theory and Computation 14 (2), 1033-1044, 2018
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors
H Zhao, G Garg, J Zhao, E Moroni, A Girgis, LS Franco, S Singh, ...
European journal of medicinal chemistry 89, 442-466, 2015
Transcription factor protein interactomes reveal genetic determinants in heart disease
B Gonzalez-Teran, M Pittman, F Felix, R Thomas, D Richmond-Buccola, ...
Cell 185 (5), 794-814. e30, 2022
Identification of a new scaffold for Hsp90 C-terminal inhibition
H Zhao, E Moroni, G Colombo, BSJ Blagg
ACS Medicinal Chemistry Letters 5 (1), 84-88, 2014
The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 spike protein
SA Serapian, F Marchetti, A Triveri, G Morra, M Meli, E Moroni, GA Sautto, ...
The Journal of Physical Chemistry Letters 11 (19), 8084-8093, 2020
MM/PBSA analysis of molecular dynamics simulations of bovine β‐lactoglobulin: Free energy gradients in conformational transitions?
F Fogolari, E Moroni, M Wojciechowski, M Baginski, L Ragona, H Molinari
Proteins: Structure, Function, and Bioinformatics 59 (1), 91-103, 2005
Design of allosteric stimulators of the Hsp90 ATPase as new anticancer leads
I D'Annessa, S Sattin, J Tao, M Pennati, C Sŕnchez‐Martěn, E Moroni, ...
Chemistry–A European Journal 23 (22), 5188-5192, 2017
The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2)
M Rusnati, P Borsotti, E Moroni, C Foglieni, P Chiodelli, L Carminati, ...
Angiogenesis 22, 133-144, 2019
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization
D Lecis, E Mastrangelo, L Belvisi, M Bolognesi, M Civera, F Cossu, ...
Bioorganic & medicinal chemistry 20 (22), 6709-6723, 2012
Machine learning prediction of allosteric drug activity from molecular dynamics
F Marchetti, E Moroni, A Pandini, G Colombo
The journal of physical chemistry letters 12 (15), 3724-3732, 2021
Impact of mutations on NPAC structural dynamics: mechanistic insights from MD simulations
M Montefiori, S Pilotto, C Marabelli, E Moroni, M Ferraro, SA Serapian, ...
Journal of Chemical Information and Modeling 59 (9), 3927-3937, 2019
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