Ondřej Benek
Ondřej Benek
postdoctoral fellow, University of Hradec Kralove
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A perspective on multi-target drugs for Alzheimer’s disease
O Benek, J Korabecny, O Soukup
Trends in pharmacological sciences 41 (7), 434-445, 2020
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment
L Hroch, P Guest, O Benek, O Soukup, J Janockova, R Dolezal, K Kuca, ...
Bioorganic & Medicinal Chemistry 25 (3), 1143-1152, 2017
A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the progression and treatment of Alzheimer’s disease
O Benek, L Aitken, L Hroch, K Kuca, F Gunn-Moore, K Musilek
Current medicinal chemistry 22 (9), 1056-1085, 2015
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease
O Benek, O Soukup, M Pasdiorova, L Hroch, V Sepsova, P Jost, ...
ChemMedChem 11 (12), 1264-1269, 2016
Benzothiazoles-scaffold of interest for CNS targeted drugs
L Hroch, L Aitken, O Benek, M Dolezal, K Kuca, F Gunn-Moore, K Musilek
Current Medicinal Chemistry 22 (6), 730-747, 2015
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment
L Hroch, O Benek, P Guest, L Aitken, O Soukup, J Janockova, K Musil, ...
Bioorganic & medicinal chemistry letters 26 (15), 3675-3678, 2016
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
O Benek, L Hroch, L Aitken, F Gunn-Moore, L Vinklarova, K Kuca, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 33 (1), 665-670, 2018
A systematic review on donepezil-based derivatives as potential cholinesterase inhibitors for Alzheimer’s disease
J Korabecny, K Spilovska, E Mezeiova, O Benek, R Juza, D Kaping, ...
Current Medicinal Chemistry 26 (30), 5625-5648, 2019
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
K Sobolova, M Hrabinova, V Hepnarova, T Kucera, T Kobrlova, ...
European journal of medicinal chemistry 203, 112593, 2020
Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential alzheimer’s disease treatment
L Aitken, O Benek, BE McKelvie, RE Hughes, L Hroch, M Schmidt, ...
Molecules 24 (15), 2757, 2019
6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17&: β-HSD10 and potential drugs for Alzheimer&
O Benek, L Hroch, L Aitken, R Dolezal, P Guest, M Benkova, O Soukup, ...
Medicinal Chemistry 13 (4), 345-358, 2017
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Z Skok, M Barančoková, O Benek, CD Cruz, P Tammela, T Tomašič, ...
ACS medicinal chemistry letters 11 (12), 2433-2440, 2020
Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
L Vinklarova, M Schmidt, O Benek, K Kuca, F Gunn‐Moore, K Musilek
Journal of Neurochemistry 155 (3), 231-249, 2020
Novel caffeine derivatives with antiproliferative activity
M Andrs, D Muthna, M Rezacova, M Seifrtova, P Siman, J Korabecny, ...
RSC advances 6 (39), 32534-32539, 2016
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro
J Honegr, D Malinak, R Dolezal, O Soukup, M Benkova, L Hroch, O Benek, ...
European Journal of Medicinal Chemistry 146, 38-46, 2018
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
M Schmidt, O Benek, L Vinklarova, M Hrabinova, L Zemanova, M Chribek, ...
International Journal of Molecular Sciences 21 (6), 2059, 2020
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases
A Haleckova, O Benek, L Zemanová, R Dolezal, K Musilek
Medicinal Research Reviews 42 (5), 1822-1855, 2022
Tacrine and its derivatives in the therapy of Alzheimers disease
J Korábečný, K Spilovská, O Benek, K Musílek, O Soukup, K Kuča
Ceska a Slovenska Farmacie: Casopis Ceske Farmaceuticke Spolecnosti a …, 2012
Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration
Z Fišar, K Musílek, O Benek, L Hroch, L Vinklářová, M Schmidt, ...
Toxicology Letters 339, 12-19, 2021
Takrin a jeho deriváty v terapii Alzheimerovy choroby
J Korábečný, K Špilovská, O Benek, K Musílek, O Soukup, K Kuča
Čes. slov. Farm 61, 210-221, 2012
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