| The interplay between cell signalling and the mevalonate pathway in cancer PJ Mullen, R Yu, J Longo, MC Archer, LZ Penn Nature Reviews Cancer 16 (11), 718-731, 2016 | 548 | 2016 |
| AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress S Sriskanthadevan, DV Jeyaraju, TE Chung, S Prabha, W Xu, M Skrtic, ... Blood, The Journal of the American Society of Hematology 125 (13), 2120-2130, 2015 | 308 | 2015 |
| Extracellular matrix remodeling regulates glucose metabolism through TXNIP destabilization WJ Sullivan, PJ Mullen, EW Schmid, A Flores, M Momcilovic, MS Sharpley, ... Cell 175 (1), 117-132. e21, 2018 | 194 | 2018 |
| Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth AS Krall, PJ Mullen, F Surjono, M Momcilovic, EW Schmid, CJ Halbrook, ... Cell metabolism 33 (5), 1013-1026. e6, 2021 | 148 | 2021 |
| MYC interacts with the G9a histone methyltransferase to drive transcriptional repression and tumorigenesis WB Tu, YJ Shiah, C Lourenco, PJ Mullen, D Dingar, C Redel, A Tamachi, ... Cancer cell 34 (4), 579-595. e8, 2018 | 107 | 2018 |
| SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition PJ Mullen, G Garcia Jr, A Purkayastha, N Matulionis, EW Schmid, ... Nature communications 12 (1), 1876, 2021 | 104 | 2021 |
| Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy PJ Mullen, B Lüscher, H Scharnagl, S Krähenbühl, K Brecht Biochemical pharmacology 79 (8), 1200-1209, 2010 | 94 | 2010 |
| Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt PJ Mullen, A Zahno, P Lindinger, S Maseneni, A Felser, S Krähenbühl, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (12), 2079-2087, 2011 | 89 | 2011 |
| Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop A Pandyra, PJ Mullen, M Kalkat, R Yu, JT Pong, Z Li, S Trudel, KS Lang, ... Cancer research 74 (17), 4772-4782, 2014 | 80 | 2014 |
| Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells CA Goard, M Chan-Seng-Yue, PJ Mullen, AD Quiroga, AR Wasylishen, ... Breast cancer research and treatment 143, 301-312, 2014 | 74 | 2014 |
| Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death AA Pandyra, PJ Mullen, CA Goard, E Ericson, P Sharma, M Kalkat, R Yu, ... Oncotarget 6 (29), 26909, 2015 | 69 | 2015 |
| Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins R Yu, J Longo, JE van Leeuwen, PJ Mullen, W Ba-Alawi, B Haibe-Kains, ... Cancer research 78 (5), 1347-1357, 2018 | 67 | 2018 |
| An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer J Longo, PJ Mullen, R Yu, JE van Leeuwen, M Masoomian, DTS Woon, ... Molecular metabolism 25, 119-130, 2019 | 62 | 2019 |
| Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo A Bonifacio, PJ Mullen, IS Mityko, LC Navegantes, J Bouitbir, ... Archives of toxicology 90, 203-215, 2016 | 58 | 2016 |
| Largen: a molecular regulator of mammalian cell size control K Yamamoto, V Gandin, M Sasaki, S McCracken, W Li, JL Silvester, ... Molecular cell 53 (6), 904-915, 2014 | 46 | 2014 |
| A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer J Longo, RJ Hamilton, M Masoomian, N Khurram, E Branchard, PJ Mullen, ... Prostate Cancer and Prostatic Diseases 23 (4), 630-637, 2020 | 43 | 2020 |
| MYC phosphorylation at novel regulatory regions suppresses transforming activity AR Wasylishen, M Chan-Seng-Yue, C Bros, D Dingar, WB Tu, M Kalkat, ... Cancer research 73 (21), 6504-6515, 2013 | 43 | 2013 |
| Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition C Setz, Y Brand, V Radojevic, C Hanusek, PJ Mullen, S Levano, A Listyo, ... Neuroscience 181, 28-39, 2011 | 23 | 2011 |
| Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells CJ Halbrook, G Thurston, S Boyer, C Anaraki, JA Jiménez, A McCarthy, ... Nature cancer 3 (11), 1386-1403, 2022 | 22 | 2022 |
| Effect of short-and long-term treatment with valproate on carnitine homeostasis in humans R Morand, L Todesco, M Donzelli, D Fischer-Barnicol, PJ Mullen, ... Therapeutic drug monitoring 34 (4), 406-414, 2012 | 15 | 2012 |
