| Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes MD Szczelkun, MS Tikhomirova, T Sinkunas, G Gasiunas, T Karvelis, ... Proceedings of the National Academy of Sciences 111 (27), 9798-9803, 2014 | 473 | 2014 |
| crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus T Karvelis, G Gasiunas, A Miksys, R Barrangou, P Horvath, V Siksnys RNA biology 10 (5), 841-851, 2013 | 330 | 2013 |
| RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX V Siksnys, G Gasiunas, T Karvelis, A Lubys, L Zaliauskiene, M Glemzaite, ... US Patent App. 14/385,857, 2015 | 241 | 2015 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiunas, T Karvelis US Patent 9,637,739, 2017 | 235 | 2017 |
| Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements T Karvelis, G Gasiunas, J Young, G Bigelyte, A Silanskas, M Cigan, ... Genome biology 16, 1-13, 2015 | 221 | 2015 |
| PAM recognition by miniature CRISPRCas12f nucleases triggers programmable double-stranded DNA target cleavage T Karvelis, G Bigelyte, JK Young, Z Hou, R Zedaveinyte, K Budre, ... Nucleic acids research 48 (9), 5016-5023, 2020 | 165 | 2020 |
| Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease T Karvelis, G Druteika, G Bigelyte, K Budre, R Zedaveinyte, A Silanskas, ... Nature 599 (7886), 692-696, 2021 | 112 | 2021 |
| A catalogue of biochemically diverse CRISPR-Cas9 orthologs G Gasiunas, JK Young, T Karvelis, D Kazlauskas, T Urbaitis, ... Nature communications 11 (1), 5512, 2020 | 112 | 2020 |
| RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX V Siksnys, G Gasiunas, T Karvelis US Patent App. 14/743,764, 2015 | 109 | 2015 |
| RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX V Siksnys, G Gasiünas, T Karvelis US Patent App. 14/683,443, 2015 | 97 | 2015 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiunas, T Karvelis, A Lubys, L Zaliauskiene, M Gasiuniene, A Smith US Patent 11,555,187, 2023 | 64 | 2023 |
| RNA-directed DNA cleavage by the Cas9-crRNA complex G Gasiūnas, T Karvelis US Patent 10,844,378, 2020 | 52 | 2020 |
| Programmable DNA cleavage in vitro by Cas9 T Karvelis, G Gasiunas, V Siksnys Biochemical Society Transactions 41 (6), 1401-1406, 2013 | 45 | 2013 |
| Miniature type VF CRISPR-Cas nucleases enable targeted DNA modification in cells G Bigelyte, JK Young, T Karvelis, K Budre, R Zedaveinyte, V Djukanovic, ... Nature communications 12 (1), 6191, 2021 | 44 | 2021 |
| Harnessing the natural diversity and in vitro evolution of Cas9 to expand the genome editing toolbox T Karvelis, G Gasiunas, V Siksnys Current Opinion in Microbiology 37, 88-94, 2017 | 36 | 2017 |
| Methods for decoding Cas9 protospacer adjacent motif (PAM) sequences: A brief overview T Karvelis, G Gasiunas, V Siksnys Methods 121, 3-8, 2017 | 34 | 2017 |
| Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex M Glemzaite, E Balciunaite, T Karvelis, G Gasiunas, MM Grusyte, ... RNA biology 12 (1), 1-4, 2015 | 27 | 2015 |
| 5′ modifications to CRISPRCas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage G Mullally, K Van Aelst, MM Naqvi, FM Diffin, T Karvelis, G Gasiunas, ... Nucleic acids research 48 (12), 6811-6823, 2020 | 23 | 2020 |
| TnpB structure reveals minimal functional core of Cas12 nuclease family G Sasnauskas, G Tamulaitiene, G Druteika, A Carabias, A Silanskas, ... Nature 616 (7956), 384-389, 2023 | 20 | 2023 |
| A pipeline for characterization of novel Cas9 orthologs T Karvelis, JK Young, V Siksnys Academic Press, 2019 | 14 | 2019 |
