Menghang Xia
Menghang Xia
National Center for Advancing Transnational Sciences, NIH
Verified email at
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High-throughput screening assays for the identification of chemical probes
J Inglese, RL Johnson, A Simeonov, M Xia, W Zheng, CP Austin, DS Auld
Nature chemical biology 3 (8), 466-479, 2007
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
M Xu, EM Lee, Z Wen, Y Cheng, WK Huang, X Qian, J Tcw, ...
Nature medicine 22 (10), 1101-1107, 2016
Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors
A Singh, S Venkannagari, KH Oh, YQ Zhang, JM Rohde, L Liu, ...
ACS chemical biology 11 (11), 3214-3225, 2016
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
WH Goodson III, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, ...
Carcinogenesis 36 (Suppl_1), S254-S296, 2015
Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action
SC Miller, R Huang, S Sakamuru, SJ Shukla, MS Attene-Ramos, P Shinn, ...
Biochemical pharmacology 79 (9), 1272-1280, 2010
Compound cytotoxicity profiling using quantitative high-throughput screening
M Xia, R Huang, KL Witt, N Southall, J Fostel, MH Cho, A Jadhav, ...
Environmental health perspectives 116 (3), 284-291, 2008
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform
SJ Shukla, R Huang, CP Austin, M Xia
Drug discovery today 15 (23-24), 997-1007, 2010
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor
RS Judson, FM Magpantay, V Chickarmane, C Haskell, N Tania, J Taylor, ...
Toxicological Sciences 148 (1), 137-154, 2015
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
T Khare, S Pai, K Koncevicius, M Pal, E Kriukiene, Z Liutkeviciute, M Irimia, ...
Nature structural & molecular biology 19 (10), 1037-1043, 2012
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
R Huang, M Xia, S Sakamuru, J Zhao, SA Shahane, M Attene-Ramos, ...
Nature communications 7 (1), 10425, 2016
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space
R Judson, K Houck, M Martin, AM Richard, TB Knudsen, I Shah, S Little, ...
Toxicological Sciences 152 (2), 323-339, 2016
The Tox21 robotic platform for the assessment of environmental chemicals–from vision to reality
MS Attene-Ramos, N Miller, R Huang, S Michael, M Itkin, RJ Kavlock, ...
Drug discovery today 18 (15-16), 716-723, 2013
Mitochondrial membrane potential assay
S Sakamuru, MS Attene-Ramos, M Xia
High-throughput screening assays in toxicology, 17-22, 2016
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
RS Judson, MT Martin, DM Reif, KA Houck, TB Knudsen, DM Rotroff, ...
Environmental science & technology 44 (15), 5979-5985, 2010
Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.
M Xia, D Leppert, SL Hauser, SP Sreedharan, PJ Nelson, AM Krensky, ...
Journal of immunology (Baltimore, Md.: 1950) 156 (1), 160-167, 1996
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors
R Huang, M Xia, MH Cho, S Sakamuru, P Shinn, KA Houck, DJ Dix, ...
Environmental health perspectives 119 (8), 1142-1148, 2011
Bisphenol A affects androgen receptor function via multiple mechanisms
C Teng, B Goodwin, K Shockley, M Xia, R Huang, J Norris, BA Merrick, ...
Chemico-biological interactions 203 (3), 556-564, 2013
Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2
SZ An, JH Yang, MH Xia, EJ Goetzl
Biochemical and biophysical research communications 197 (1), 263-270, 1993
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Z Li, M Brecher, YQ Deng, J Zhang, S Sakamuru, B Liu, R Huang, ...
Cell research 27 (8), 1046-1064, 2017
Tox21Challenge to build predictive models of nuclear receptor and stress response pathways as mediated by exposure to environmental chemicals and drugs
R Huang, M Xia, DT Nguyen, T Zhao, S Sakamuru, J Zhao, SA Shahane, ...
Frontiers in Environmental Science 3, 85, 2016
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