| Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦ A Demuro, E Mina, R Kayed, SC Milton, I Parker, CG Glabe Journal of Biological Chemistry 280 (17), 17294-17300, 2005 | 1306 | 2005 |
| The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers A Penna, A Demuro, AV Yeromin, SL Zhang, O Safrina, I Parker, ... Nature 456 (7218), 116-120, 2008 | 511 | 2008 |
| Calcium signaling and amyloid toxicity in Alzheimer disease A Demuro, I Parker, GE Stutzmann Journal of Biological Chemistry 285 (17), 12463-12468, 2010 | 500 | 2010 |
| SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production KN Green, A Demuro, Y Akbari, BD Hitt, IF Smith, I Parker, FM LaFerla The Journal of cell biology 181 (7), 1107-1116, 2008 | 359 | 2008 |
| Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology A Demuro, M Smith, I Parker Journal of Cell Biology 195 (3), 515-524, 2011 | 218 | 2011 |
| CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes Z Ma, A Taruno, M Ohmoto, M Jyotaki, JC Lim, H Miyazaki, N Niisato, ... Neuron 98 (3), 547-561. e10, 2018 | 169 | 2018 |
| Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate A Demuro, I Parker Journal of Neuroscience 33 (9), 3824-3833, 2013 | 141 | 2013 |
| Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins AP Siebert, Z Ma, JD Grevet, A Demuro, I Parker, JK Foskett Journal of Biological Chemistry 288 (9), 6140-6153, 2013 | 127 | 2013 |
| “Optical Patch-clamping” Single-channel Recording by Imaging Ca2+ Flux through Individual Muscle Acetylcholine Receptor Channels A Demuro, I Parker The Journal of general physiology 126 (3), 179-192, 2005 | 127 | 2005 |
| Imaging the activity and localization of single voltage-gated Ca2+ channels by total internal reflection fluorescence microscopy A Demuro, I Parker Biophysical journal 86 (5), 3250-3259, 2004 | 114 | 2004 |
| Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states A Demuro, A Penna, O Safrina, AV Yeromin, A Amcheslavsky, ... Proceedings of the National Academy of Sciences 108 (43), 17832-17837, 2011 | 113 | 2011 |
| Imaging single-channel calcium microdomains A Demuro, I Parker Cell calcium 40 (5-6), 413-422, 2006 | 104 | 2006 |
| Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin Z Tan, W Dai, TGM van Erp, J Overman, A Demuro, MA Digman, A Hatami, ... Molecular psychiatry 20 (11), 1286-1293, 2015 | 72 | 2015 |
| Inhibition of nicotinic acetylcholine receptors by bicuculline A Demuro, E Palma, F Eusebi, R Miledi Neuropharmacology 41 (7), 854-861, 2001 | 58 | 2001 |
| γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices F Berton, A Brancucci, F Beghè, M Cammalleri, A Demuro, W Francesconi, ... European journal of pharmacology 380 (2-3), 109-116, 1999 | 49 | 1999 |
| Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes A Demuro, I Parker Cell calcium 34 (6), 499-509, 2003 | 45 | 2003 |
| Optical single-channel recording: imaging Ca 2+ flux through individual ion channels with high temporal and spatial resolution A Demuro, I Parker Journal of biomedical optics 10 (1), 011002-011002-8, 2005 | 37 | 2005 |
| cADPR stimulates SERCA activity in Xenopus oocytes M Yamasaki-Mann, A Demuro, I Parker Cell calcium 45 (3), 293-299, 2009 | 36 | 2009 |
| Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging A Demuro, I Parker Cell calcium 43 (4), 367-374, 2008 | 36 | 2008 |
| Analyzing and modeling the kinetics of amyloid beta pores associated with Alzheimer’s disease pathology G Ullah, A Demuro, I Parker, JE Pearson PloS one 10 (9), e0137357, 2015 | 35 | 2015 |
Ian ParkerEmeritus Distinguished Professor, University of California, IrvineVerified email at uci.edu
