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Jonathan Kingsbury
Jonathan Kingsbury
Verified email at sanofi.com
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Year
A single molecular descriptor to predict solution behavior of therapeutic antibodies
JS Kingsbury, A Saini, SM Auclair, L Fu, MM Lantz, KT Halloran, ...
Science Advances 6 (32), eabb0372, 2020
992020
The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal: direct analysis by fluorescence-detected analytical ultracentrifugation
JS Kingsbury, TM Laue, ES Klimtchuk, R Théberge, CE Costello, ...
Journal of biological chemistry 283 (18), 11887-11896, 2008
732008
Fluorescence-detected sedimentation in dilute and highly concentrated solutions
JS Kingsbury, TM Laue
Methods in enzymology 492, 283-304, 2011
482011
Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry
JS Kingsbury, R Théberge, JA Karbassi, A Lim, CE Costello, LH Connors
Analytical chemistry 79 (5), 1990-1998, 2007
482007
Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin
JS Kingsbury, ES Klimtchuk, R Théberge, CE Costello, LH Connors
Protein expression and purification 53 (2), 370-377, 2007
382007
Valence and anion binding of bovine ribonuclease A between pH 6 and 8
TP Moody, JS Kingsbury, JA Durant, TJ Wilson, SF Chase, TM Laue
Analytical biochemistry 336 (2), 243-252, 2005
352005
Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action
H Qiu, E Boudanova, A Park, JJ Bird, DM Honey, C Zarazinski, B Greene, ...
Bioconjugate chemistry 24 (3), 408-418, 2013
292013
Machine learning feature selection for predicting high concentration therapeutic antibody aggregation
PK Lai, A Fernando, TK Cloutier, JS Kingsbury, Y Gokarn, KT Halloran, ...
Journal of Pharmaceutical Sciences 110 (4), 1583-1591, 2021
282021
Impact of cysteine variants on the structure, activity, and stability of recombinant human α‐galactosidase A
H Qiu, DM Honey, JS Kingsbury, A Park, E Boudanova, RR Wei, CQ Pan, ...
Protein Science 24 (9), 1401-1411, 2015
272015
Ultradilute measurements of self-association for the identification of antibodies with favorable high-concentration solution properties
CG Starr, EK Makowski, L Wu, B Berg, JS Kingsbury, YR Gokarn, ...
Molecular Pharmaceutics 18 (7), 2744-2753, 2021
232021
Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties
A Park, DM Honey, L Hou, JJ Bird, C Zarazinski, M Searles, C Braithwaite, ...
Endocrinology 154 (3), 1373-1383, 2013
212013
Detection of high-molecular-weight amyloid serum protein complexes using biological on-line tracer sedimentation
JS Kingsbury, TM Laue, SF Chase, LH Connors
Analytical biochemistry 425 (2), 151-156, 2012
102012
A Single Molecular Descriptor to Predict Solution Behavior of Therapeutic Antibodies. Sci. Adv. 6 (32), eabb0372
JS Kingsbury, A Saini, SM Auclair, L Fu, MM Lantz, KT Halloran, ...
82020
Combining scattering experiments and colloid theory to characterize charge effects in concentrated antibody solutions
A Gulotta, M Polimeni, S Lenton, CG Starr, A Stradner, E Zaccarelli, ...
Molecular Pharmaceutics, 2023
12023
Characterization of opalescence in low volume monoclonal antibody solutions enabled by microscale nephelometry
JS Kingsbury, MM Lantz, A Saini, MZ Wang, YR Gokarn
Journal of Pharmaceutical Sciences 110 (9), 3176-3182, 2021
12021
Means for antibody characterization
Y Gokarn, J Kingsbury, CG Starr, PM Tessier
US Patent App. 18/269,118, 2024
2024
Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations
JJ Janke, CG Starr, JS Kingsbury, N Furtmann, CJ Roberts, ...
The Journal of Physical Chemistry B, 2024
2024
Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies
MA Rodrigues, A Duarte, V Geraldes, JS Kingsbury, P Sanket, V Filipe, ...
European Journal of Pharmaceutics and Biopharmaceutics 192, 174-184, 2023
2023
AF4 and PEG Precipitation as Predictive Assays for Antibody Self-Association
I Condado-Morales, V Sokolova, PO Wahlund, KE Heding, S Auclair, ...
Molecular Pharmaceutics 20 (2), 1323-1330, 2023
2023
Preformulation of New Biological Entities
R Torosantucci, V Filipe, J Kingsbury, A Saluja, Y Gokarn
Parenteral Medications, Fourth Edition, 69-91, 2019
2019
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