| Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist K Beaumont, R Webster, I Gardner, K Dack Current drug metabolism 4 (6), 461-485, 2003 | 517 | 2003 |
| In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist KJ Af Forselles, J Root, T Clarke, D Davey, K Aughton, K Dack, N Pullen British journal of pharmacology 164 (7), 1847-1856, 2011 | 160 | 2011 |
| Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib Q Huang, TW Johnson, S Bailey, A Brooun, KD Bunker, BJ Burke, ... Journal of medicinal chemistry 57 (4), 1170-1187, 2014 | 121 | 2014 |
| Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists C Guo, A Linton, S Kephart, M Ornelas, M Pairish, J Gonzalez, S Greasley, ... Journal of medicinal chemistry 54 (21), 7693-7704, 2011 | 76 | 2011 |
| Metalloprotease inhibitors KN Dack, MJ Fray, GA Whitlock, ML Lewis, NM Thomson US Patent 6,511,993, 2003 | 69 | 2003 |
| A mild and selective C-3 reductive alkylation of indoles JE Appleton, KN Dack, AD Green, J Steele Tetrahedron letters 34 (9), 1529-1532, 1993 | 65 | 1993 |
| Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ... Journal of medicinal chemistry 55 (5), 2173-2184, 2012 | 60 | 2012 |
| The design and synthesis of a novel series of indole derived selective ETA antagonists DJ Rawson, KN Dack, RP Dickinson, K James Bioorganic & medicinal chemistry letters 12 (2), 125-128, 2002 | 44 | 2002 |
| Acidic triazoles as soluble guanylate cyclase stimulators LR Roberts, PA Bradley, ME Bunnage, KS England, D Fairman, ... Bioorganic & medicinal chemistry letters 21 (21), 6515-6518, 2011 | 36 | 2011 |
| Composition for the treatment of damaged tissue K Dack, M Davies, P Fish, J Huggins, F McIntosh, N Occleston US Patent App. 10/131,985, 2003 | 36 | 2003 |
| Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors KN Dack, GA Whitlock US Patent 6,495,568, 2002 | 36 | 2002 |
| Thromboxane modulating agents. 3. 1 H-Imidazol-1-ylalkyl-and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl) amino] ethyl] benzenepropanoic acid derivatives as dual … RP Dickinson, KN Dack, CJ Long, J Steele Journal of medicinal chemistry 40 (21), 3442-3452, 1997 | 33 | 1997 |
| Triazole compounds useful in therapy RD Armour, AD Baxter, JS Bryans, KN Dack, PS Johnson, RA Lewthwaite, ... US Patent 7,084,145, 2006 | 32 | 2006 |
| Indole derivatives thromboxane A2 antagonists PE Cross, KN Dack, RP Dickinson, J Steele US Patent 5,744,488, 1998 | 31 | 1998 |
| A novel series of highly selective inhibitors of MMP-3 GA Whitlock, KN Dack, RP Dickinson, ML Lewis Bioorganic & medicinal chemistry letters 17 (24), 6750-6753, 2007 | 28 | 2007 |
| Composition for the treatment of damaged tissue K Dack, M Davies, P Fish, J Huggins, F McIntosh, N Occleston US Patent App. 10/901,417, 2005 | 26 | 2005 |
| Substituted alpha-aminosulphonyl-acetohydroxamic acids as therapeutic agents KN Dack, GA Whitlock US Patent 6,090,852, 2000 | 25 | 2000 |
| Fragment-based discovery of 6-arylindazole JAK inhibitors A Ritzén, MD Sørensen, KN Dack, DR Greve, A Jerre, MA Carnerup, ... ACS Medicinal Chemistry Letters 7 (6), 641-646, 2016 | 24 | 2016 |
| Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors MS Glossop, RJ Bazin, KN Dack, DNA Fox, GA MacDonald, M Mills, ... Bioorganic & medicinal chemistry letters 21 (11), 3404-3406, 2011 | 23 | 2011 |
| Compounds useful in therapy PA Bradley, KN Dack, IR Marsh US Patent 7,482,375, 2009 | 19* | 2009 |
John SteeleIndependentVerified email at steele5.com
