Helen S. Toogood
Helen S. Toogood
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Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
HS Toogood, JM Gardiner, NS Scrutton
ChemCatChem 2 (8), 892-914, 2010
Discovery, characterization, engineering, and applications of ene-reductases for industrial biocatalysis
HS Toogood, NS Scrutton
ACS catalysis 8 (4), 3532-3549, 2018
New developments in ‘ene’-reductase catalysed biological hydrogenations
HS Toogood, NS Scrutton
Current opinion in chemical biology 19, 107-115, 2014
Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak. 1 protease at 1.8 ┼ resolution
CA Smith, HS Toogood, HM Baker, RM Daniel, EN Baker
Journal of molecular biology 294 (4), 1027-1040, 1999
Asymmetric reduction of activated alkenes by pentaerythritol tetranitrate reductase: specificity and control of stereochemical outcome by reaction optimisation
A Fryszkowska, H Toogood, M Sakuma, JM Gardiner, GM Stephens, ...
Advanced synthesis & catalysis 351 (17), 2976-2990, 2009
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme
AJ Warman, O Roitel, R Neeli, HM Girvan, HE Seward, SA Murray, ...
Biochemical Society Transactions 33 (4), 747-753, 2005
Biocatalysis with thermostable enzymes: structure and properties of a thermophilic ‘ene’‐reductase related to old yellow enzyme
BV Adalbj÷rnsson, HS Toogood, A Fryszkowska, CR Pudney, TA Jowitt, ...
ChemBioChem 11 (2), 197-207, 2010
Dynamics driving function− new insights from electron transferring flavoproteins and partner complexes
HS Toogood, D Leys, NS Scrutton
The FEBS journal 274 (21), 5481-5504, 2007
Extensive domain motion and electron transfer in the human electron transferring flavoproteinĚ medium chain Acyl-CoA dehydrogenase complex
HS Toogood, A Van Thiel, J Basran, MJ Sutcliffe, NS Scrutton, D Leys
Journal of Biological Chemistry 279 (31), 32904-32912, 2004
Structure‐based insight into the asymmetric bioreduction of the C C double bond of α, β‐unsaturated nitroalkenes by pentaerythritol tetranitrate reductase
HS Toogood, A Fryszkowska, V Hare, K Fisher, A Roujeinikova, D Leys, ...
Advanced synthesis & catalysis 350 (17), 2789-2803, 2008
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli
AJ Jervis, P Carbonell, M Vinaixa, MS Dunstan, KA Hollywood, ...
ACS synthetic biology 8 (1), 127-136, 2018
Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets: new heme ligation states influence conformational equilibria iná…
HM Girvan, HE Seward, HS Toogood, MR Cheesman, D Leys, AW Munro
Journal of Biological Chemistry 282 (1), 564-572, 2007
Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases
I Ahel, C Stathopoulos, A Ambrogelly, A Sauerwald, H Toogood, ...
Journal of Biological Chemistry 277 (38), 34743-34748, 2002
Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli
HS Toogood, AN Cheallaigh, S Tait, DJ Mansell, A Jervis, A Lygidakis, ...
ACS Synthetic Biology 4 (10), 1112-1123, 2015
A site‐saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity
HS Toogood, A Fryszkowska, M Hulley, M Sakuma, D Mansell, ...
ChemBioChem 12 (5), 738-749, 2011
Low carbon strategies for sustainable bio-alkane gas production and renewable energy
M Amer, EZ Wojcik, C Sun, R Hoeven, JMX Hughes, M Faulkner, ...
Energy & Environmental Science 13 (6), 1818-1831, 2020
The use of a thermostable signature amidase in the resolution of the bicyclic synthon (rac)-γ-lactam
HS Toogood, RC Brown, K Line, PA Keene, SJC Taylor, R McCague, ...
Tetrahedron 60 (3), 711-716, 2004
Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site‐saturated libraries
ME Hulley, HS Toogood, A Fryszkowska, D Mansell, GM Stephens, ...
ChemBioChem 11 (17), 2433-2447, 2010
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum
DJ Mansell, HS Toogood, J Waller, JMX Hughes, CW Levy, JM Gardiner, ...
ACS catalysis 3 (3), 370-379, 2013
A thermostable L-aminoacylase from Thermococcus litoralis: cloning, overexpression, characterization, and applications in biotransformations
HS Toogood, EJ Hollingsworth, RC Brown, IN Taylor, SJ Taylor, ...
Extremophiles 6, 111-122, 2002
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