Colin Levy
Colin Levy
University of Manchester, Manchester Protein Structure Facility
Verified email at
Cited by
Cited by
Molecular basis of triclosan activity
CW Levy, A Roujeinikova, S Sedelnikova, PJ Baker, AR Stuitje, ...
Nature 398 (6726), 383-384, 1999
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ...
Nature 517 (7535), 513-516, 2015
Better than nature: nicotinamide biomimetics that outperform natural coenzymes
T Knaus, CE Paul, CW Levy, S De Vries, FG Mutti, F Hollmann, ...
Journal of the American Chemical Society 138 (3), 1033-1039, 2016
The structure of Mycobacterium tuberculosis CYP125
KJ McLean, P Lafite, C Levy, MR Cheesman, N Mast, IA Pikuleva, D Leys, ...
Journal of Biological Chemistry 284 (51), 35524-35533, 2009
Structural basis of kynurenine 3-monooxygenase inhibition
M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ...
Nature 496 (7445), 382-385, 2013
Directed evolution of an efficient and thermostable PET depolymerase
EL Bell, R Smithson, S Kilbride, J Foster, FJ Hardy, S Ramachandran, ...
Nature Catalysis 5 (8), 673-681, 2022
The road to fully programmable protein catalysis
SL Lovelock, R Crawshaw, S Basler, C Levy, D Baker, D Hilvert, ...
Nature 606 (7912), 49-58, 2022
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen
MD Driscoll, KJ McLean, C Levy, N Mast, IA Pikuleva, P Lafite, SEJ Rigby, ...
Journal of biological chemistry 285 (49), 38270-38282, 2010
Crystallographic analysis of triclosan bound to enoyl reductase
A Roujeinikova, CW Levy, S Rowsell, S Sedelnikova, PJ Baker, ...
Journal of molecular biology 294 (2), 527-535, 1999
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes
SA Shepherd, C Karthikeyan, J Latham, AW Struck, ML Thompson, ...
Chemical science 6 (6), 3454-3460, 2015
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
AJ Burke, SL Lovelock, A Frese, R Crawshaw, M Ortmayer, M Dunstan, ...
Nature 570 (7760), 219-223, 2019
Updated structure of Drosophila cryptochrome
C Levy, BD Zoltowski, AR Jones, AT Vaidya, D Top, J Widom, MW Young, ...
Nature 495 (7441), E3-E4, 2013
Synthesis and biological evaluation of coumarin-based inhibitors of NAD (P) H: quinone oxidoreductase-1 (NQO1)
KA Nolan, JR Doncaster, MS Dunstan, KA Scott, AD Frenkel, D Siegel, ...
Journal of medicinal chemistry 52 (22), 7142-7156, 2009
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
S Zhang, DJ Heyes, L Feng, W Sun, LO Johannissen, H Liu, CW Levy, ...
Nature 574 (7780), 722-725, 2019
Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase
B Khara, N Menon, C Levy, D Mansell, D Das, ENG Marsh, D Leys, ...
ChemBioChem 14 (10), 1204, 2013
Crystal structure of a soluble form of human CD73 with ecto‐5′‐nucleotidase activity
DPHM Heuts, MJ Weissenborn, RV Olkhov, AM Shaw, J Gummadova, ...
Chembiochem 13 (16), 2384-2391, 2012
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction
CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton
Journal of the American Chemical Society 131 (47), 17072-17073, 2009
A structure‐guided switch in the regioselectivity of a tryptophan halogenase
SA Shepherd, BRK Menon, H Fisk, AW Struck, C Levy, D Leys, ...
ChemBioChem 17 (9), 821-824, 2016
Catalytic determinants of alkene production by the cytochrome P450 peroxygenase OleTJE
S Matthews, JD Belcher, KL Tee, HM Girvan, KJ McLean, SEJ Rigby, ...
Journal of Biological Chemistry 292 (12), 5128-5143, 2017
Structure‐guided directed evolution of alkenyl and arylmalonate decarboxylases
K Okrasa, C Levy, M Wilding, M Goodall, N Baudendistel, B Hauer, ...
Angewandte Chemie 121 (41), 7827-7830, 2009
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