|Short-term in vivo exposure to the water contaminant triclosan: evidence for disruption of thyroxine|
KM Crofton, KB Paul, MJ DeVito, JM Hedge
Environmental toxicology and pharmacology 24 (2), 194-197, 2007
|The next generation blueprint of computational toxicology at the US Environmental Protection Agency|
RS Thomas, T Bahadori, TJ Buckley, J Cowden, C Deisenroth, ...
Toxicological Sciences 169 (2), 317-332, 2019
|Short-term Exposure to Triclosan Decreases Thyroxine In Vivo via Upregulation of Hepatic Catabolism in Young Long-Evans Rats|
KB Paul, JM Hedge, MJ DeVito, KM Crofton
Toxicological Sciences 113 (2), 367-379, 2010
|Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action|
KB Paul, JM Hedge, R Bansal, RT Zoeller, R Peter, MJ DeVito, ...
Toxicology 300 (1-2), 31-45, 2012
|Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization|
K Paul Friedman, M Gagne, LH Loo, P Karamertzanis, T Netzeva, ...
Toxicological Sciences 173 (1), 202-225, 2020
|Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast phase I and II chemical libraries|
K Paul Friedman, ED Watt, MW Hornung, JM Hedge, RS Judson, ...
Toxicological Sciences 151 (1), 160-180, 2016
|Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats|
KB Paul, JM Hedge, MJ DeVito, KM Crofton
Environmental Toxicology and Chemistry 29 (12), 2840-2844, 2010
|Development of a thyroperoxidase inhibition assay for high-throughput screening|
KB Paul, JM Hedge, DM Rotroff, MW Hornung, KM Crofton, SO Simmons
Chemical research in toxicology 27 (3), 387-399, 2014
|In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis|
NC Kleinstreuer, DJ Dix, KA Houck, RJ Kavlock, TB Knudsen, MT Martin, ...
toxicological sciences 131 (1), 40-55, 2013
|Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches|
PD Noyes, KP Friedman, P Browne, JT Haselman, ME Gilbert, ...
Environmental health perspectives 127 (9), 095001, 2019
|Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors|
KB Paul, JT Thompson, SO Simmons, JPV Heuvel, KM Crofton
Toxicology in vitro 27 (7), 2049-2060, 2013
|ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses|
S Watford, LL Pham, J Wignall, R Shin, MT Martin, KP Friedman
Reproductive Toxicology 89, 145-158, 2019
|Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling|
J Nyffeler, C Willis, R Lougee, A Richard, K Paul-Friedman, JA Harrill
Toxicology and applied pharmacology 389, 114876, 2020
|An exposure: activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept|
RA Becker, KP Friedman, TW Simon, MS Marty, G Patlewicz, ...
Regulatory Toxicology and Pharmacology 71 (3), 398-408, 2015
|Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library|
K Paul-Friedman, M Martin, KM Crofton, CW Hsu, S Sakamuru, J Zhao, ...
Environmental health perspectives 127 (9), 097009, 2019
|Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat|
KB Paul, JM Hedge, C Macherla, DL Filer, E Burgess, SO Simmons, ...
Toxicology 312, 97-107, 2013
|High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis|
DE Haggard, AL Karmaus, MT Martin, RS Judson, RW Setzer, ...
Toxicological Sciences 162 (2), 509-534, 2018
|Variability in in vivo studies: Defining the upper limit of performance for predictions of systemic effect levels|
LL Pham, SM Watford, P Pradeep, MT Martin, RS Thomas, RS Judson, ...
Computational Toxicology 15, 100126, 2020
|A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study|
K Paul Friedman, S Papineni, MS Marty, KD Yi, AK Goetz, RJ Rasoulpour, ...
Critical Reviews in Toxicology 46 (9), 785-833, 2016
|Evaluation of chemical effects on network formation in cortical neurons grown on microelectrode arrays|
TJ Shafer, JP Brown, B Lynch, S Davila-Montero, K Wallace, KP Friedman
Toxicological Sciences 169 (2), 436-455, 2019