| Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α, β-heterodimers and microtubules JJ Field, B Pera, E Calvo, A Canales, D Zurwerra, C Trigili, ... Chemistry & biology 19 (6), 686-698, 2012 | 103 | 2012 |
| Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane JJ Field, B Pera, E Calvo, A Canales, D Zurwerra, C Trigili, ... | 103* | |
| THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors F Cayrol, P Praditsuktavorn, TM Fernando, N Kwiatkowski, R Marullo, ... Nature communications 8, 14290, 2017 | 101 | 2017 |
| Thermodynamics as a Tool for the Optimization of Drug Binding R Matesanz, B Pera, JF Díaz Thermodynamics-Interaction Studies-Solids, Liquids and Gases, 2011 | 91* | 2011 |
| Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents A Milelli, V Tumiatti, M Micco, M Rosini, G Zuccari, L Raffaghello, ... European journal of medicinal chemistry 57, 417-428, 2012 | 60 | 2012 |
| New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism B Pera, I Barasoain, A Pantazopoulou, A Canales, R Matesanz, ... ACS chemical biology 8 (9), 2084-2094, 2013 | 59 | 2013 |
| PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors M Martínez-Díez, MJ Guillén-Navarro, B Pera, BP Bouchet, ... Biochemical pharmacology 88 (3), 291-302, 2014 | 58 | 2014 |
| Cpl-7, a lysozyme encoded by a pneumococcal bacteriophage with a novel cell wall-binding motif N Bustamante, NE Campillo, E García, C Gallego, B Pera, GP Diakun, ... Journal of Biological Chemistry 285 (43), 33184-33196, 2010 | 58 | 2010 |
| Combinatorial epigenetic therapy in diffuse large B cell lymphoma pre-clinical models and patients B Pera, T Tang, R Marullo, SN Yang, H Ahn, J Patel, R Elstrom, J Ruan, ... Clinical epigenetics 8 (1), 79, 2016 | 44 | 2016 |
| Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances R Matesanz, C Trigili, J Rodríguez-Salarichs, I Zanardi, B Pera, A Nogales, ... Bioorganic & medicinal chemistry 22 (18), 5078-5090, 2014 | 39 | 2014 |
| Modulation of microtubule interprotofilament interactions by modified taxanes R Matesanz, J Rodríguez-Salarichs, B Pera, A Canales, JM Andreu, ... Biophysical journal 101 (12), 2970-2980, 2011 | 35 | 2011 |
| BCL6 evolved to enable stress tolerance in vertebrates and is broadly required by cancer cells to adapt to stress TM Fernando, R Marullo, BP Gresely, JM Phillip, SN Yang, ... Cancer discovery, CD-17-1444, 2019 | 34 | 2019 |
| Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity B Pera, M Razzak, C Trigili, O Pineda, A Canales, RM Buey, ... ChemBioChem 11 (12), 1669-1678, 2010 | 34 | 2010 |
| Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway B Pera, J Krumsiek, SE Assouline, R Marullo, J Patel, JM Phillip, L Román, ... EBioMedicine, 2018 | 28 | 2018 |
| Mechanism of action of the cytotoxic macrolides amphidinolide X and J C Trigili, B Pera, M Barbazanges, J Cossy, C Meyer, O Pineda, ... ChemBioChem 12 (7), 1027-1030, 2011 | 25 | 2011 |
| Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site E Calvo, I Barasoain, R Matesanz, B Pera, E Camafeita, O Pineda, ... Biochemistry 51 (1), 329-341, 2011 | 23 | 2011 |
| A structure-based design of new C2-and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure–activity relationships using comparative binding … C Coderch, Y Tang, J Klett, SE Zhang, YT Ma, W Shaorong, R Matesanz, ... Organic & biomolecular chemistry 11 (18), 3046-3056, 2013 | 22 | 2013 |
| The Binding Mode of Side Chain‐and C3‐Modified Epothilones to Tubulin M Erdélyi, A Navarro‐Vázquez, B Pfeiffer, CN Kuzniewski, A Felser, ... ChemMedChem 5 (6), 911-920, 2010 | 20 | 2010 |
| High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells B Pera, MN Calvo-Vidal, S Ambati, M Jordi, A Kahn, JF Díaz, W Fang, ... Cancer letters 368 (1), 97-104, 2015 | 18 | 2015 |
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites JJ Field, B Pera, JE Gallego, E Calvo, J Rodríguez-Salarichs, ... Journal of Natural Products, 2017 | 15 | 2017 |
