Priyanka Prakash
Priyanka Prakash
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Lipid-sorting specificity encoded in K-Ras membrane anchor regulates signal output
Y Zhou, P Prakash, H Liang, KJ Cho, AA Gorfe, JF Hancock
Cell 168 (1), 239-251. e16, 2017
Oncogenic K-Ras binds to an anionic membrane in two distinct orientations: a molecular dynamics analysis
P Prakash, Y Zhou, H Liang, JF Hancock, AA Gorfe
Biophysical journal 110 (5), 1125-1138, 2016
Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers
P Prakash, A Sayyed-Ahmad, KJ Cho, DM Dolino, W Chen, H Li, BJ Grant, ...
Scientific reports 7 (1), 40109, 2017
Spatiotemporal analysis of K-Ras plasma membrane interactions reveals multiple high order homo-oligomeric complexes
S Sarkar-Banerjee, A Sayyed-Ahmad, P Prakash, KJ Cho, MN Waxham, ...
Journal of the American Chemical Society 139 (38), 13466-13475, 2017
Ras and the plasma membrane: a complicated relationship
Y Zhou, P Prakash, AA Gorfe, JF Hancock
Cold Spring Harbor perspectives in medicine 8 (10), a031831, 2018
Discovery of high-affinity noncovalent allosteric KRAS inhibitors that disrupt effector binding
MJ McCarthy, CV Pagba, P Prakash, AK Naji, D van der Hoeven, H Liang, ...
ACS omega 4 (2), 2921-2930, 2019
•Binding hotspots on K-Ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis
P Prakash, J Hancock, A Gorfe
Proteins, 2015
Dynamics of membrane-bound G12V-KRAS from simulations and single-molecule FRET in native nanodiscs
P Prakash, D Litwin, H Liang, S Sarkar-Banerjee, D Dolino, Y Zhou, ...
Biophysical journal 116 (2), 179-183, 2019
Lessons from computer simulations of Ras proteins in solution and in membrane
P Prakash, AA Gorfe
Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (11), 5211-5218, 2013
AMPK and endothelial nitric oxide synthase signaling regulates K-Ras plasma membrane interactions via cyclic GMP-dependent protein kinase 2
K Cho, DE Casteel, P Prakash, L Tan, D van der Hoeven, AA Salim, ...
Molecular and Cellular Biology, 2016
A “tug of war” maintains a dynamic protein–membrane complex: molecular dynamics simulations of C-Raf RBD-CRD bound to K-Ras4B at an anionic membrane
ZL Li, P Prakash, M Buck
ACS central science 4 (2), 298-305, 2018
The role of conserved waters in conformational transitions of Q61H K-ras
P Prakash, A Sayyed-Ahmad A, Gorfe
Plos Computational Biology 8 (2), e1002394, 2012
Distinct dynamics and interaction patterns in H‐and K‐Ras oncogenic P‐loop mutants
A Sayyed‐Ahmad, P Prakash, AA Gorfe
Proteins: Structure, Function, and Bioinformatics 85 (9), 1618-1632, 2017
Membrane orientation dynamics of lipid-modified small GTPases
P Prakash, AA Gorfe
Small GTPases 8 (3), 129-138, 2017
Probing the conformational and energy landscapes of KRAS membrane orientation
P Prakash, AA Gorfe
The Journal of Physical Chemistry B 123 (41), 8644-8652, 2019
Multi‐target, ensemble‐based virtual screening yields novel allosteric KRAS inhibitors at high success rate
AK Gupta, X Wang, CV Pagba, P Prakash, S Sarkar‐Banerjee, J Putkey, ...
Chemical biology & drug design 94 (2), 1441-1456, 2019
pMD-membrane: A method for ligand binding site identification in membrane-bound protein
P Prakash, A Sayyed-Ahmad, A Gorfe
PloS Compuational Biology, 2015
Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocholine micelles
P Prakash, A Sayyed-Ahmad, Y Zhou, DE Volk, DG Gorenstein, E Dial, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (12), 3040-3047, 2012
The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure
Y Zhou, PS Prakash, H Liang, AA Gorfe, JF Hancock
Proceedings of the National Academy of Sciences 118 (6), e2014605118, 2021
Computational allosteric ligand binding site identification on Ras proteins
M Mccarthy, P Prakash, A Gorfe
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