Derren Heyes
Derren Heyes
Manchester Institute of Biotechnology, University of Manchester
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Making light work of enzyme catalysis: protochlorophyllide oxidoreductase
DJ Heyes, CN Hunter
Trends in biochemical sciences 30 (11), 642-649, 2005
Conformational changes in an ultrafast light-driven enzyme determine catalytic activity
OA Sytina, DJ Heyes, CN Hunter, MT Alexandre, IHM Van Stokkum, ...
Nature 456 (7224), 1001-1004, 2008
Structural basis of kynurenine 3-monooxygenase inhibition
M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ...
Nature 496 (7445), 382-385, 2013
Enzymology below 200 K: the kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase
DJ Heyes, AV Ruban, HM Wilks, CN Hunter
Proceedings of the National Academy of Sciences 99 (17), 11145-11150, 2002
Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase
DJ Heyes, M Sakuma, SP de Visser, NS Scrutton
Journal of Biological Chemistry 284 (6), 3762-3767, 2009
Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase
DJ Heyes, CN Hunter, IHM van Stokkum, R Van Grondelle, ML Groot
Nature Structural & Molecular Biology 10 (6), 491-492, 2003
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase
NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ...
Biochemistry 50 (19), 4121-4131, 2011
Protochlorophyllide oxidoreductase:“dark” reactions of a light-driven enzyme
DJ Heyes, AV Ruban, CN Hunter
Biochemistry 42 (2), 523-528, 2003
Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates
A Hernández-Ortega, MG Quesne, S Bui, DJ Heyes, RA Steiner, ...
Journal of the American Chemical Society 137 (23), 7474-7487, 2015
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1: analysis of CO complexation reactions and reversibility of the P450 …
AJ Dunford, KJ McLean, M Sabri, HE Seward, DJ Heyes, NS Scrutton, ...
Journal of Biological Chemistry 282 (34), 24816-24824, 2007
The first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex
DJ Heyes, P Heathcote, SEJ Rigby, MA Palacios, R van Grondelle, ...
Journal of Biological Chemistry 281 (37), 26847-26853, 2006
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
S Zhang, DJ Heyes, L Feng, W Sun, LO Johannissen, H Liu, CW Levy, ...
Nature 574 (7780), 722-725, 2019
Photochemical mechanism of light-driven fatty acid photodecarboxylase
DJ Heyes, B Lakavath, SJO Hardman, M Sakuma, TM Hedison, ...
ACS catalysis 10 (12), 6691-6696, 2020
Identification and characterization of the product release steps within the catalytic cycle of protochlorophyllide oxidoreductase
DJ Heyes, CN Hunter
Biochemistry 43 (25), 8265-8271, 2004
NADPH: protochlorophyllide oxidoreductase from Synechocystis: overexpression, purification and preliminary characterisation
DJ Heyes, GEM Martin, RJ Reid, CN Hunter, HM Wilks
Febs Letters 483 (1), 47-51, 2000
Enzymatic carboxylation of 2-furoic acid yields 2, 5-furandicarboxylic acid (FDCA)
KAP Payne, SA Marshall, K Fisher, MJ Cliff, DM Cannas, C Yan, ...
ACS catalysis 9 (4), 2854-2865, 2019
Molecular basis of halorespiration control by CprK, a CRP‐FNR type transcriptional regulator
C Levy, K Pike, DJ Heyes, MG Joyce, K Gabor, H Smidt, J Van Der Oost, ...
Molecular microbiology 70 (1), 151-167, 2008
Quantum biology: An update and perspective
Y Kim, F Bertagna, EM D’Souza, DJ Heyes, LO Johannissen, ET Nery, ...
Quantum Reports 3 (1), 80-126, 2021
Low carbon strategies for sustainable bio-alkane gas production and renewable energy
M Amer, EZ Wojcik, C Sun, R Hoeven, JMX Hughes, M Faulkner, ...
Energy & Environmental Science 13 (6), 1818-1831, 2020
Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases
S Brenner, DJ Heyes, S Hay, MA Hough, RR Eady, SS Hasnain, ...
Journal of Biological Chemistry 284 (38), 25973-25983, 2009
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